
Two Virginia Tech scientists may have invented the future of cancer treatment—a way to eradicate tumors without the harmful side effects of chemotherapy, radiation or a surgeon’s scalpel.
They’ve built what chemist Karen Brewer calls a “molecular machine” that seeks out fast-replicating cancer cells and becomes lethal only when exposed to light.
Other photodynamic therapies rely on drugs that grab oxygen molecules from nearby tissue, so they are powerless against dense, fast-growing cancers—such as breast, brain, lung and prostate—with hypoxic, or oxygen-free, cores.
“I really wanted to come up with something completely different, a light-activated drug that would not require oxygen,” says Brewer, an expert at building light-triggered on/off switches for chemical compounds.